Through her creativity and resilience, Lois Mailou Jones shattered the constraints placed upon her by society, championing the value and visibility of women and people of color in art.

Her art encompasses various mediums, including oil painting, watercolor, textiles, and fashion design. Her paintings, perhaps the most celebrated of her creations, often feature bold colors, intricate patterns, and themes that reflect her deep appreciation for African and Caribbean art and the vibrancy of African-American culture. This multifaceted approach mirrors broader trends in the Harlem Renaissance and the Négritude (an anti-colonial cultural, political movement founded by a group of African and Caribbean students in Paris in the 1930s who sought to reclaim the value of blackness and African Culture) movement, with contemporaries like Aaron Douglas and William H. Johnson also exploring African themes and aesthetics in their art.

Jones uniquely blended these influences with European and post-impressionist elements, a synthesis derived from her studies and experiences in Paris. This blend of styles and cultural references highlighted the richness of the African diaspora and its contributions to global culture. It parallelled other artists of her time who engaged in cross-cultural dialogues through their art.

Her legacy serves as a beacon of inspiration, illustrating the profound impact one individual can have in transforming and enhancing our understanding and appreciation of diverse cultures and perspectives.